Testolactone / Teslac

Vegas

Testolactone/Teslac Profile ~ By *****


Chemical Name: 17 alpha-oxa-D-homo-1,4-androstadiene-3,17-dione
Molecular Weight: 300.3968
Molecular Formula: C19 H24 O3
Active Life: 24 hours


Testolactone was originally used medically for the treatment of estrogen-dependant breast cancer, first being approved for use in 1970. It is a first generation non-selective steroidal aromatase inhibitor. Like mesterolone, testolactone is steroidal in structure, but is most often used for it’s anti-estrogenic abilities. The anabolic effects of this drug are negligible and should only be relied upon for its role as an aromatase inhibitor. It offers the same advantages of other aromatase inhibitors, namely protection against gynocomastia, water retention, etc.

Testolactone is not suppressive to a user’s natural hormonal production. In fact it has been shown to help increase testosterone, raise leutenizing hormone levels, as well as follicle stimulating hormone (1,2). This is definitely something that would interest bodybuilders and strength athletes. Some users have used testolactone during their post-cycle therapy for these effects and it would appear that it is quite effective for such a purpose. In fact, it also offers the advantage that it can not desensitize the leydig cells as human chorionic gonadotropin can.

Testolactone does not bind or activate the androgen receptor as it does not have an active 17-beta-hydroxyl group. Its D ring is a six membered lactone ring. The norm is to have a five membered carboxylic ring, as testosterone has. It may actually have an anti-androgenic effect as it can interact with the androgen receptor (3). Testolactone is able to block testosterone and other steroids from attaching to the androgen receptor because of this.


Use/Dosing

Maximum estrogen suppression with testolactone is achieved at about 250 milligrams per day (1). Many uses will see the results that they are hoping for with doses that are slightly lower than this. As indicated earlier, many users will administer this compound both during their cycle as well as post-cycle to help recover their natural testosterone production. Due to the active life of the drug, it should be administered at least once per day.


Risks/Side Effects

Users of the compound have not reported any significant side effects with the use of this drug and there is really no damage that users could do to themselves by administering this compound even for lengthy periods of time, other than those associated with suppressing estrogen levels. However be advised that there are very few studies regarding this compound for long term use and anyone undertaking a lengthy cycle will be doing so at their own risk.


References

1. Leinonen P, Bolton NJ, Kontturi M, Vihko R. Rapid endocrine effects of tamoxifen and testolactone in prostatic carcinoma patients. Prostate 1982; 3(6):589-97

2. Martikainen H, Ruokonen A, Ronnberg L, Vihko R. Short-term effects of testolactone on human testicular steroid production and on the response to human chorionic gonadotropin. Fertil Steril 1985 May;43(5):793-8

3. Vigersky RA, Mozingo D, Eil C, Purohit V, Bruton J. The antiandrogenic effects of delta 1-testolactone (Teslac) in vivo in rats and in vitro in human cultured fibroblasts, rat mammary carcinoma cells, and rat prostate cytosol. Endocrinology 1982 Jan; 110(1):214-9