Dinitrophenol (DNP)

Narkissos

Dinitrophenol (DNP)


Depositor-supplied Synonyms:
2, 4-Dinitrophenol
Nitrophene
Nitrophen
Aldifen
Nitro kleenup
Dinitrofenolo
Dinofan
Fenoxyl carbon N
Chemox PE
Dinitrophenols

Dinitrophenol (DNP)
Molecular Weight: 184.106
Molecular Formula: C6H4N2O5
Melting Point: 112-114 Degrees Celsius
Manufacturer: Various
Trade Names: Caswell No. 392; Sulfo Black B; Nitro Kleenup.
Half-Life: 36 hours

Physical Description: Yellowish crystals, of sand- like appearance. 2,4-Dinitrophenol is moderately soluble in water. Concentrations of between 1 to 1,000 milligrams will mix with a litre of water. 2,4-Dinitrophenol is volatile with steam.

Odour: It has a sweet, musty odour.

Stability: DNP is stable but flammable, since it essentially is an explosive compound. Dust explosion is possible if it is in powder or granular form, mixes with air.

Shipping Method: 2, 4-Dinitrophenol is shipped and handled in a 15% solution of water. Shipping/Handling as a paste prevents explosion due to shock or friction.

Handling Information: When handling DNP, the user is required to wear gloves at all times. DNP, in raw powder form, will stain almost anything that it touches… so keep that in mind. If you are making tabs on your own, stay in a ventilated area but make sure the DNP does not become airborne i.e. don’t sit close to a fan, or beside an open window.

Therapeutic Dosage: 2milligrams of DNP per kilogram of bodyweight per day
Typical Dosage Range: 200 mg- 1000 mg**
Recommended Administration: Once Daily

**NB 2, 4-Dinitrophenol is a Poison! It is not a supplement or a dietary aid and is not recommended for human consumption.

DNP is a manufactured toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant (Stedman, 26th ed). DNP has been used in wood preservatives and Insecticides. It has been used as reagent for detection of potassium and ammonium ions. It’s also used in photo chemicals and explosives. It was administered to patients in diet pills in the 1930’s. In 1938 it was deemed hazardous and it was banned. Medically, DNP is quite dangerous. The body has no negative feedback system that may deal with overdoses. Specifically, there is no upper limit to the increase in body temperature that may be obtained with DNP use. DNP is still available since it is still used in manufacturing of dyes, wood preservatives, poison, insecticide, etc.



Acute Effects:
• Acute oral exposure to high levels of 2, 4-dinitrophenol in humans has resulted in increased basal metabolic rate, nausea, vomiting, sweating, dizziness, headache, loss of weight, and other symptoms.

• The substance may cause effects on metabolism, resulting in very high body temperature. Exposure may result in death.

• 2, 4-Dinitrophenol is considered to have high acute toxicity, based on short-term animal tests in rats and mice.

Chronic Effects (Non cancer):
• Chronic oral exposure to 2, 4-dinitrophenol in humans and animals has resulted in the formation of cataracts and skin lesions and has caused effects on the bone marrow, CNS, and cardiovascular system.

• The Reference Dose (RfD) for 2, 4-dinitrophenol is 0.002 milligrams per kilogram body weight per day (mg/kg/d) based on cataract formation in humans. The RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily oral exposure to the human population (including sensitive subgroups), that is likely to be without appreciable risk of deleterious non cancer effects during a lifetime. It is not a direct estimator of risk but rather a reference point to gauge the potential effects. At exposures increasingly greater than the RfD, the potential for adverse health effects increases. Lifetime exposure above the RfD does not imply that an adverse health effect would necessarily occur.

• EPA has low confidence in the study on which the RfD was based since this study only describes anecdotal data; low confidence in the database since the supporting database is meagre; and, consequently, low confidence in the RfD.
• EPA has not established a Reference Concentration (RfC) for 2, 4-dinitrophenol.

Cancer Hazard :

• nil


• 2, 4-Dinitrophenol Not only has not a single test found it to be carcinogenic, but test after test after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%.

• Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it’s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer…fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

Reproductive Hazard

• 2, 4-Dinitrophenol may damage the developing fetus.

• 2, 4-Dinitrophenol has not been tested for its ability to adversely affect reproduction.

How it works:
DNP is an uncoupling agent that inhibits the flow of electrons and the pumping of H+ ions for ATP synthesis. Fifty years ago it was used for weight loss; however, in 1938 the FDA removed it from the counter, as it caused cataracts and even sometimes death. If electron transport does not produce ATP, then much more sugar must be metabolized for energy needs. Very low production of ATP would be lethal. In oxidative phosphorylation, the flow of electrons from NADH (the reduced form of NAD+, oxidized from NAD. This enzyme is important in accepting electrons in the course of metabolic reactions. When NAD+ gives up its electron, it is converted to its reduced form NADH) and FADH2 (the reduced form of FAD) to oxygen results in the pumping of H+ from the matrix to the inner membrane space of the mitochondria. This gradient of H+ can produce ATP by flowing through ATP synthetase in the mitochondrial inner membrane. Dinitrophenol disrupts the H+ gradient reducing ATP synthesis. Under these conditions, much of the food that we eat could not be used for ATP synthesis and we lose weight. It is proposed that, too much inhibitor and we could make too little ATP for life.

The difference between weight loss and death is only a small concentration change in Dinitrophenol. This factor alone makes the drug dangerous. Simply put, this means that while eating your normal diet, you will experience effects similar to that of having ingested between 20% and 40% less calories.
Dosing Information: Typically 2milligrams of DNP per kilogram of bodyweight per day is enough to produce noticeable results. This’d generally result in fat-loss of 5-10lbs in 8-14 days, but results will vary since individuals each have a unique genetic make up. DNP usually comes in tabs of 200mg concentration, so most people start off at 200mg.

A first time user shouldn’t go over 200mg daily (one tablet everyday). One can slowly increase the dose if one feels that the sides aren’t increasing too much. Experienced users have been known to use up to 1000mg a day. This is definitely not advised, even if you have used DNP before because it could be potentially fatal.

Typical Cycle: Day 1-20 200mg

Mentioned above is a beginner's cycle. Do not increase the dose after the first few days if you don’t ‘feel anything’.

Here’s why:
The half-life of 2,4 Dinitrophenol is 36 hours. So, after 36 hours, there is 50% of the DNP remaining in your system. Therefore, 72 hours later 25% remains. Then 12.5% remains after 108 hours. After 5 days (at the 120-hour point), there's roughly 9% of the DNP left in your body. This, compounded with daily administration of 200mg, means that at every point during the cycle, circulatory DNP levels are above 200 mg. An increase in dosage, by a novice user, can have dangerous repercussions.


After day 4 then you can assess your tolerance and accordingly increase your dosage. But I would still stay at 200mg since its your first run. After you have run DNP and are familiar with it, and how your body reacts to it, then you can start to increase doses.

Precautions:
Refrain from too much strenuous activity while you are taking DNP, (don’t do too much cardio) Your body is pretty much running a 24 hour marathon since your metabolism is increased, which in turn burns a lot more calories so extensive cardio isn’t necessary. But in no way does this mean that you can just sit on your ass and eat whatever you want and still lose a ton of weight.

Diet has to be solid, with high protein and moderate carbs, and cardio should be kept in moderation (45mins to an hour 4-7times a week) depending on how you react. You must also be sure to keep yourself hydrated AT ALL TIMES. Dnp has a funny way of making you think you’re not thirsty when your body really is in need of water. I can’t stress this enough, drink 1-2gallons of water everyday. If you don’t, you can die! It’s also a good idea to monitor your temperature throughout the day just in case it has risen to dangerous levels, in which case you should seek medical attention. You will be sweating a lot so it’s a good idea to get a fan. Sleep under a fan with your windows open, hell sleep naked without any covers if you can , otherwise your sheets will be pretty soaked in the morning.

In addition: Avoid under any circumstance, consuming alcohol or any other diuretic substance while on a DNP cycle. The above-mentioned compounds raise the risk of dehydration. Dehydration while on DNP can result in death!!!

Recommended Supplements:

1. The ECA stack: an anorectant. DNP raises Neuro-peptide Y levels in the brain, which is directly linked to increased hunger. Consuming 75-100mg total of ephedrine alkaloids/day should be sufficient to suppress appetite. PPA (Nor-ephedrine) should NOT be used as it enhances lethargy when combined with DNP. Sibutramine can also be used as an appetite suppressant.

2. Anti-oxidants. Due to the DNP-induced rapid combustion of fats, free-radical production skyrockets up-wards. To combat this, anti-oxidants must be used. Anti-oxidants are the single most important supplement to take on a DNP cycle.
• a) Fat-soluble Anti-O: Vitamin E: 1000mgs/day
• b) Water-soluble Anti-O: Vitamin C: 2-3g/day
• c) Alpha Lipoic acid: 600-1000mgs/day

Dual-anti-oxidant: BOTH fat & water-soluble actually re-cycles other anti-oxidants.

3. A multivitamin.

4. Glycerol: Although optional, glycerol is often consumed at 15ml's 3X/day. Glycerol increases hydration for many athletes.

5. Water: Not a supplement, but an absolute necessity:
DNP causes sweating and can be incredibly dehydrating. Dehydration is the NUMBER ONE cause of most DNP problems and deaths. Excessive dehydration results in over-heating. Dieters who do not replenish fluids properly while on a DNP cycle can and do die. The consensus among athletes is that at least two gallons of water must be consumed daily.

5. FRUIT... Yes i said Fruit!!!
Fruit for some reason has been found to greatly reduce the lethargy associated with a DNP cycle. It also has a high water content, therefore it helps to keep the dieter hydrated.

6. Benadryl: an anti-Histamine. DNP has been found to cause allergic reactions (e.g. hives) in some users.

7. Additionally (optional): Taurine; potassium gluconate; Milk Thistle; grapeseed extract; cranberry extract; green tea; tyrosin; Glutamine; zinc; Melatonin.

References:
Spectrum Laboratories: Chemical Fact Sheet CAS # 51285

2, 4-Dinitrophenol – CAS 51285 Catalogue of Chemical Suppliers

U.S Environmental Protection Agency (Air Toxics Website) 2, 4-Dinitrophenol

Pub Chem Chemical Profile 2, 4-Dinitrophenol

National Library of Medicine; 2, 4-Dinitrophenol

http://www.cyberiron.com/drugs/dinitrophenol.html

www.xtrememass.com (DNP information)

http://www.elitefitness.com/articledata/efn/111901.html (DNP supplementation)

Author: Maxmuscle187

Editor: Narkissos

Posted at: Ironforlife.com

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BTS

Great profile Nark, very informative, thanks

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Narkissos

Sorry the profiles took so long. I had al the research on my PC but no time. I came accross this forum last nite. Didn't know any profiles had been posted..so i spent all day putting the info together...adding info to Max's profile...and finishing mine.

Hope y'all like it.

This is number two of the three i've received. The third being Mondo's Halo profile. *****'s done a Halo profile and it's already been posted so that's it for me for now. Feel free to send me some more.

~Corey

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Golgo13

Best profile I have found... Most boards don't have a profile on it at all.

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Syndicate

Great info, as I didnt quite understand how DNP worked and its exact effects. I will definently be more cautious when thinking of using this now.

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LeanMeOut

Good stuff Nark :)

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Mesomorphyl

I agree that certain types of fruit witll help with lethargy as it helps with cellular ATP, this is why I suggest pyruvate during a DNP run. Pyruvate will give you the benifits of certain fruits and increase ATP for energy.

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Narkissos

Thanks LMO...BUMP! For Max...

Agreed Meso...but fruit just tastes so much better

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Maraxus

Good stuff bro

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turd ferguson

This is a good profile. Im glad to see the ETC and uncoupling actions of dnp described well and acurately.

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oh...and rob...go meep yourself

Narkissos

bump for the dnp heads

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Mallet

Great fat burner but i did develop eczema on my right shin from running dnp. no more dnp for me...

Great info Nark!

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Hide

What is the peptime on DNP?

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mar1122

Maraxus

against forum rules.

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