Bodybuilding Health & Fitness Forum - Iron for Life - Humalog Administration...reduces insulin resistance

10-22-2005, 04:56 AM

Narkissos

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Humalog Administration...reduces insulin resistance

reveiw: http://care.diabetesjournals.org/cg...t/full/24/3/430

conclusion:

Quote:

The DCCT and other studies proved the importance of good blood glucose control in preventing eye, kidney, and nerve complications in people with both type 1 (127,8). Unfortunately, when the DCCT results were released, the only way to achieve better glucose control was more daily injections associated with more daily blood glucose tests, or the use of an insulin pump-delivery system. To the best of our knowledge, this is the first report to show a decline in HbA1c values in a general diabetes clinic after the DCCT report. The decline in HbA1c was most dramatic in teenagers and adults in the first year after the DCCT. These were the age-groups in which the DCCT data were shown to be applicable. Unfortunately, values leveled off between 1994 and 1996. In this study, the decline in HbA1c values from 1993 to 1996 in adults was significantly related to the use of intensive therapy. As described in the DCCT (1), and as found in this study, the incidence of severe hypoglycemic events increased. The increase continued in 1995 and 1996, even though HbA1c levels stabilized, presumably due to the continued attempts to lower values and the occurrence of "hypoglycemia-unawareness" with the greater duration of tighter control. The realization of the need for improved glycemic control, associated with a two- to threefold increase in severe hypoglycemic episodes, led to displeasure from both diabetes care providers (9) and patients.

Our study showed that the introduction of Humalog insulin made it possible to obtain the goal of improved blood glucose control without any further increase in severe hypoglycemic episodes. Alternative explanations for these outcomes might be the patient cohort changing during the study period, advances in glucose monitoring, insulin administration, increased familiarity with intensive diabetes management, and educational strategies. Humalog insulin resulted in lower postprandial blood glucose levels in every study in comparison with values after regular insulin (10–13). This was primarily because of higher insulin levels 30 to 90 min after injection, which closely matched food absorption. Many studies also showed a decline in severe hypoglycemic episodes (10–14), particularly during the nighttime. In addition, the frequency of hypoglycemic events in people using insulin pumps declined when Humalog was used in the pump rather than regular insulin (15–18).

Although the U.S. Food and Drug Administration initially approved Humalog only for children older than 12 years of age and adults, we and most others began using it in patients of all ages (19,20). Humalog was particularly helpful in children younger than 5 years of age with variable appetites. In toddlers with type 1 diabetes, postprandial administration of Humalog showed lower postprandial glucose excursions when compared with preprandial human regular insulin (20). In the current trial, the major reasons for not changing to Humalog insulin were the physician’s choice, insurance companies not willing to reimburse the cost of Humalog, and lower socioeconomic status.

The decline in HbA1c levels after the introduction of Humalog occurred without an increase in the number of severe hypoglycemic episodes. Instead, a decrease in the number of severe episodes was found. This result is particularly important in young children, in whom severe episodes may result in brain damage (21,22). Patients and health care providers are more likely to accept intensive insulin therapy if it does not result in a greater risk for severe hypoglycemia (which can result in death).

As described in the DCCT (5), the 13- to 18-year age-group had the highest level of HbA1c values. Increased insulin resistance in this age-group is one possible cause for such values (23,24). It is likely that behavior (including food choices) and psychological issues may also contribute to the higher HbA1c values in teens. The 5- to 12-year age-group probably had lower HbA1c values because puberty and insulin resistance were not yet present and because parents have more control and influence over diabetes care during this period. Although we only recommend HbA1c values <9.3% in toddlers, when the brain is still growing and hypoglycemia can often not be recognized, their HbA1c values were not as high as might have been anticipated. Clearly, the adult group consistently had the best HbA1c values, probably because of lack of insulin resistance and better understanding of diabetes.

In conclusion, HbA1c levels declined in all four age-groups after the DCCT. Unfortunately, in concurrence with the findings of the DCCT, the number of severe hypoglycemic episodes increased. However, a second significant decline in HbA1c values occurred with the introduction of Humalog insulin. Fortunately, the incidence of severe hypoglycemic episodes did not increase after Humalog therapy. It will be important with future changes in care (e.g., introduction of continuous glucose monitoring) to document changes in HbA1c levels as well as in the incidence of severe hypoglycemic events in diabetes clinic populations of all ages

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10-22-2005, 05:51 AM	#2
*Stout1* Most Sexy Member Join Date: Apr 2005 Posts: 1,258 \| Points: 31852.85 (Donate) Rep Power: 5122	So In Eglish what does this mean Nark? :) __________________ MOD @ Powerbuilding.net MOD @ FitnessGeared.com ASST. MOD @ MuscleSci.com

10-22-2005, 02:23 PM	#3
*taiboxa* Small Penis Council Join Date: Apr 2005 Location: OkLaHoMa Posts: 8,562 \| Points: 2033.14 (Donate) Rep Power: 67483	Nark give me ur thoughts plz the bolding helped alot but im add/dyslexic/slow __________________ DECA where is you?!

10-22-2005, 08:42 PM

Narkissos

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Quote:

Originally Posted by Stout1

So In Eglish what does this mean Nark? :)

In English you mean?

It means that Humalog does something that none of the other insulin analogues does... i.e. reduces insulin resistance

reveiw the post-prandial (i.e. post-training) application especially.

10-22-2005, 08:49 PM	#5
*taiboxa* Small Penis Council Join Date: Apr 2005 Location: OkLaHoMa Posts: 8,562 \| Points: 2033.14 (Donate) Rep Power: 67483	so i kan run humalog for like 5 wk spurts instead of 4? __________________ DECA where is you?!

10-22-2005, 08:52 PM

Narkissos

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Quote:

Originally Posted by taiboxa

so i kan run humalog for like 5 wk spurts instead of 4?

It'd be akin to bad advice if i instructed you to change your protocol due to the statements of one study...but yes.. that's what this is illustrating

It is also showing another reason why log should be used preferentially over humulin-R

Humulin-R can't reduce insulin resistance.

10-22-2005, 08:57 PM	#7
*taiboxa* Small Penis Council Join Date: Apr 2005 Location: OkLaHoMa Posts: 8,562 \| Points: 2033.14 (Donate) Rep Power: 67483	DOOOD THINK OF IT slin that kan be used INDEFINETLY! dam im getting euphoric just thinkin about it __________________ DECA where is you?!

10-23-2005, 03:33 PM

Narkissos

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Quote:

Originally Posted by taiboxa

DOOOD THINK OF IT

slin that kan be used INDEFINETLY!

dam im getting euphoric just thinkin about it

I'm in the process of brainstorming a perpetual cycle article.

I'll post it in the Slin/gh forum for input...that'll determine if i take it on as writing exercise.

"Coming to forum near you"...lol

10-25-2005, 04:06 AM

KING

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The sheer thought of this makes me wanna touch myself.

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Originally Posted by Ronnie Coleman

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10-25-2005, 03:06 PM	#10
RedBaron HGH/IGF/SLIN Moderator Join Date: Apr 2005 Posts: 489 \| Points: 155.50 (Donate) Rep Power: 5531950	What I am seeing in this study is that the use of Humalog on insulin dependent diabetics provides a superior way to keep the hemoglobin A1c percentages at reasonable levels without having severe periods of going hypo. The hemoglobin A1c is a test that shows the overall average of your blood glucose levels over three months. It measures in the form of the percentage of sugars that are sticking to your red blood cells, and due to the reasonable lifespan of a red blood-cell, it gives a nice long term picture, and as such is a superior marker for diabetics in finding out what their BG levels are really doing over the course of days and weeks. The average for a normal person would be 4% - 6%. The goal for a diabetic is to keep it under 7%. The part where they are talking about replacing longer lasting insulin in the pumps makes sense. Since an insulin pump delivers several short bursts of insulin throughout the day for type 1 diabetics, using a shorter acting, harder hitting insulin like Humalog is certainly going to be more controllable than one that lasts all day. In that scenario, the longer lasting insulins are going to create difficulty in metering the pump dose as the doses stack up later in the day and cause a potentially bad, long lasting episode of hypoglycemia. Humalog gets in a clears out right away. I am not sure you could conclude from this article that Humalog reduces insulin resistance ... it merely states that Humalog is superior in diabetic (especially those dependant on the insulin pumps) in controlling their Hemoglobin A1c without a lot of episodes of blood sugar dropping into hypo territory. A type 1 diabetic has no choice but to use some kind of insulin, so the more success they have without suffering from hypoglycemia, the better. Any of us that have experienced hypo can certainly sympathize. For a normal person, that isn't going to necessarily equate to a lower instance of insulin resistance ... whatever the type of insulin used in a normal person, if you raise the average level of circulating insulin over a long enough period of time, you body's tissues will protect themselves by building a resistance to the elevated levels of insulin. Even in diabetics, over the course of time insulin dependant ones have to increase their doses. I have been in emergency situations where in an obese diabetic 500 IU's of insulin had to be administered at one time to lower BG levels sufficiently. The problem there is that over the course of time, a diabetic becomes resistant to the effects of insulin. That is why it is imperitive for them to use it wisely and in conjunction with the many medications that are at our disposal these days. At any rate, there is no argument that Humalog is a great insulin to have as a tool. It hits hard and gets out of the system fast ... thus less problems with hypo hours after administration, and less likelihood of long term problems ... but even so if it is taken long enough in great enough doses, your body will definitely build a resistance to it. If that occurs, you will certainly have to either increase the doses (a bad road to travel) or use medications (actos, avandia) and supps (k-ala, chromium, etc., etc.) to assist in keeping your body's resistance to supraphysiological levels of insulin in check.

10-25-2005, 05:52 PM

#11

KING

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Way to rain on my parade Red.

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Quote:

Originally Posted by Ronnie Coleman

Everybody wants to be a bodybuilder, but ain't nobody want to lift this heavy ass weight.

10-25-2005, 06:02 PM

#12

RedBaron

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Quote:

Originally Posted by Vito

Way to rain on my parade Red.

I know, sorry about that

.... It would be FANTASTIC if perpetual, long term use actually HELPED our overall profile ... the body's systems are almost too smart at times ... hard to trick them into a continued path of constant improvement without it trying to buck the system and compensate.

10-27-2005, 03:22 PM	#13
Narkissos Um ghey mun Join Date: Apr 2005 Location: Barbados Posts: 6,973 \| Points: 14793.20 (Donate) Rep Power: 1614147	Interesting interpretation Red...and probably spot-on. Guess i was too eager...dammit the love of slin I've got thoughts on it...but i'll have to get some research to support it __________________ ________ -Corey Springer Owner of: http://www.narkside.com http://www.getnarked.net/ (NarkSide Nutrition Forum) http://www.cafepress.com/NarkSide http://www.facebook.com/NarkSide